Bisley started his career doing magazine and album covers, his first work being a T-shirt design for heavy metal magazine Kerrang! Eventually, even though he had no experience in comics strip drawing at the time, he was hired by the magazine 2000 AD after they saw his interpretations of their magazine characters. According to the Comic Book Database, "while still a student, Bisley did a painting of a robot holding a baby that he sent to the offices of 2000 AD. The image was seen by Pat Mills and inspired him to relaunch the ABC Warriors strip, with Bisley as artist, in 1987". He started with work on ABC Warriors in 1987, later moving to Sláine and Judge Dredd. Since 1997, Bisley is a regular contributor of the comics magazine Heavy Metal. Bisley has done design work for several music videos, including Chippendales' "Room Service".